Siegel, RL et al. Colorectal cancer statistics, 2020 [J]. Ca-a Cancer J. Clinic. 70(3), 145–164 (2020).
Google Scholar
Ferlay, J. et al. Estimated Global Cancer Incidence and Mortality in 2018: Sources and Methods GLOBOCAN [J]. Int. J.Cancer 144(8), 1941-1953 (2019).
Decker, E. et al. Colorectal cancer [J]. Lancet 394(10207), 1467–1480 (2019).
Him, inf. et al. Rising global incidence of early-onset colorectal cancer across 5 continents: a joint regression analysis of 1,922,167 cases [J]. Cancer epidemiology. Biomarkers Prev. 28(8), 1275-1282 (2019).
Thanikachalam, K., Khan G. Colorectal cancer and nutrition [J]. Nutrients, 11(1), 164 (2019).
Wilkins, T., McMechan, D., and Talukder, A. Screening and prevention of colorectal cancer [J]. A m. Family Doctor 97(10), 658–665 (2018).
Inadomi, J. & Jung, B. Recent Advances in Colorectal Cancer and Future Challenges [J]. Gastroenterology 158(2), 289-290 (2020).
Modest, DP, Pant, S. & Sartore-Bianchi, A. Sequencing treatment in metastatic colorectal cancer [J]. EUR. J.Cancer 10970–83 (2019).
Wilkinson, AN et al. Colorectal cancer screening for patients with a family history of colorectal cancer or adenomas [J]. Can Fam Physician 65(11), 784–789 (2019).
Clark, SK Management of Genetically Determined Colorectal Cancer [J]. Surgeon 17(3), 165-171 (2019).
Jin, K. et al. Update on the microenvironment, epigenetics and immunotherapy of colorectal cancer [J]. Int. Immunopharmacol. 89(Pt A), 107041 (2020).
Shan, MM & Sun, SC The multiple roles of RAB GTPases in female and male meiosis [J]. Hmm. Repr. Update 27(6), 1013-1029 (2021).
Wang, W., Jia, WD, Hu, B. & Pan, YY RAB10 overexpression promotes tumor growth and indicates poor prognosis in hepatocellular carcinoma [J]. Oncotarget 8(16), 26434–26447 (2017).
Yuan, Z. & Wei, W. RAB5A promotes filopodia formation in pancreatic cancer cells via cdc42 and integrin β1 activation [J]. Biochemistry. Biophys. Res. Common. 53554–59 (2021).
Chen, P., Chen, G., Wang, C. & Mao, C. RAB13 as a Novel Prognostic Marker Promotes Proliferation and Chemotherapy Resistance in Gastric Cancer [J]. Biochemistry. Biophys. Res. Common. 519(1), 113-120 (2019).
Jeong, BY et al. Rab25 increases cancer cell invasiveness through an integrin β1/EGFR/VEGF-A/Snail signaling axis and fascin expression [J]. Exp. Mol. Med. 50(1), e435 (2018).
Ostrowski, M. et al. Rab27a and Rab27b control different steps of the exosome secretion pathway [J]. Nat. Cell Biol. 12(1), 19–30 (2010).
Guo, D. et al. RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes [J]. Int. J.Cancer 144(12), 3070–3085 (2019).
Van Solinge, TS et al. Versatile role of Rab27a in glioma: effects on extracellular vesicle release, cell viability and tumor progression [J]. Front. Mol. Biosci. seven554649 (2020).
Tang, L., Wei, D. & Yan, F. MicroRNA-145 functions as a tumor suppressor by targeting matrix metalloproteinase 11 and Rab GTPase 27a family in triple negative breast cancer [J]. Cancer Gene Ther. 23(8), 258-265 (2016).
Guo, D. et al. Abrogation of RAB27A expression transiently affects melanoma cell proliferation [J]. Pigment Cell Melanoma Res. 33(6), 889–894 (2020).
Guo, D. et al. RAB27A/Melanophilin blocker inhibits melanoma cell motility and invasion [J]. J. Invest. Dermatol. 140(7), 1470–3.e3 (2020).
Wang, H. et al. Rab27a has been identified as a prognostic biomaker by mRNA profiling, correlated with malignant progression and subtype preference in gliomas [J]. PLOS ONE 9(2), e89782 (2014).
Fen, F. et al. NF-κB-mediated Rab27A promotes colon cancer cell strain via upregulation of cytokine secretion [J]. Oncotarget seven(39), 63342–63351 (2016).
Dong, W. et al. Decreased expression of Rab27A and Rab27B correlates with metastasis and poor prognosis of colorectal cancer [J]. Discovered. Med. 20(112), 357–367 (2015).
Laughlin, KM et al. Depletion of expressed hematopoietic and neurological sequence 1 (Hn1) in B16.F10 melanoma cells promotes a differentiated phenotype that includes increased melanogenesis and cell cycle arrest [J]. Differentiation 78(1), 35–44 (2009).
Dong, WW et al. Differential Rab27A/B expression correlates with clinical outcomes in hepatocellular carcinoma [J]. World J. Gastroenterol. 18(15), 1806-1813 (2012).
You, F. et al. Prognostic significance of Rab27A and Rab27B expression in esophageal squamous cell carcinoma [J]. Cancer Management Res. 126353–6361 (2020).
A, HJ et al. RAB27A is an independent prognostic factor in clear cell carcinoma of the kidney [J]. Biomark Med. 13(4), 239–247 (2019).
Huang, Z. & Feng, Y. Exosomes derived from hypoxic colorectal cancer cells promote angiogenesis through Wnt4-induced β-catenin signaling in endothelial cells [J]. Oncol. Res. 25(5), 651–661 (2017).
Zhang, X. et al. Upregulation of miR-582-5p inhibits cell proliferation, cell cycle progression and invasion by targeting Rab27a in human colorectal carcinoma [J]. Cancer Gene Ther. 22(10), 475–480 (2015).
Shi, C. et al. Elevated expression of Rab27A indicates favorable prognosis in CRC [J]. Diagn Pathol. ten68 (2015)
Amornphimoltham, P. et al. Rab25 regulates invasion and metastasis in head and neck cancer [J]. Clin. Cancer Res. 19(6), 1375-1388 (2013).
Tong, M. et al. Rab25 is a tumor suppressor gene with anti-angiogenic and anti-invasive activities in esophageal squamous cell carcinoma [J]. Cancer Res. 72(22), 6024–6035 (2012).
Zhang, J. et al. Rab25 overexpression contributes to bladder cancer metastasis through induction of epithelial-mesenchymal transition and activation of Akt/GSK-3β/Snail signaling [J]. Carcinogenesis 34(10), 2401-2408 (2013).
Catz, SD Regulation of vesicle trafficking and leukocyte function by Rab27 GTPases and their effectors [J]. J. Leukoc. Biol. 94(4), 613–622 (2013).
Elstak, Ed. et al. The munc13-4-rab27 complex is specifically required to attach secretory lysosomes to the plasma membrane [J]. Blood 118(6), 1570-1578 (2011).
Singh, RK et al. Distinct and Opposing Roles of Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in Mast Cell Secretion [J]. Febs J. 280(3), 892–903 (2013).
Hendrix, A. & De Wever, O. Rab27 GTPases distribute extracellular nanomaps for invasive growth and metastasis: implications for prognosis and treatment [J]. Int. J.Mol. Science. 14(5), 9883–9892 (2013).
Chang, A. et al. Exosomal circPACRGL promotes colorectal cancer progression via the miR-142-3p/miR-506-3p-TGF-β1 axis [J]. Mol. Cancer 19(1), 117 (2020).
Ji, Q. et al. Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through the formation of fibroblast niches [J]. Nat. Common. 11(1), 1211 (2020).
Zhao, S. et al. Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote colorectal cancer liver metastasis [J]. J Hematol. Oncol. 13(1), 156 (2020).
Dong, P. et al. BMAL1 induces colorectal cancer metastasis by stimulating exosome secretion [J]. Mol. Biol. representing 49(1), 373–384 (2022).
Pan, Y. et al. Granulin epithelin precursor promotes colorectal carcinogenesis by activating the MARK/ERK pathway [J]. J. Trad. Med. 16(1), 150 (2018).
Cheng, B., Rong, A., Zhou, Q. & Li, W. CLDN8 promotes proliferation, migration and invasion of colorectal cancer cells by activating MAPK/ERK signaling [J]. Cancer Management Res. 113741–3751 (2019).
Tang, J. et al. hnRNPA2B1 promotes colon cancer progression via the MAPK pathway [J]. Front. Broom. 12666451 (2021)
Zhang, X., Liu, T., Huang, J. & He, J. PICALM exerts a role in promoting CRC progression through the ERK/MAPK signaling pathway [J]. Cancer Cell Int. 22(1), 178 (2022).